ABSTRACT
Objective To analyze the changes and clinical significance of serum Endostatin(ES)and vascular endothelial growth factor(VEGF)levels in patients with differentiated thyroid cancer after surgical resection or metastasis.Methods Seventy-three patients with differentiated thyroid carcinoma from January 2014 to January 2016 were enrolled in the study(the case group), all patients underwent radical thyroidectomy.The patients were divided into the distant metastasis group(32 cases),local recurrence group (23 cases)and non recurrence group(18 cases)according to local recurrence or distant metastasis after operation.40 healthy outpatients were selected as the control group.The serum levels of ES and VEGF in each group were compared,and the correlation were analyzed.Results In the preoperative time,the serum ES( (31.27±7.53)μg/mL)and VEGF((456.81 ± 112.49)ng/L)levels in the case group were significantly higher than those in the control group((20.93±4.14)μg/mL,(118.27±34.09)ng/L),the differences were statistically significant(t=8.034,18.540,P<0.05);the postoperative serum ES((25.76±6.69)μg/mL)and VEGF((217.64±56.87)ng/L)levels were significantly lower than the preoperative ones,the differences were statistically significant(t=4.674,16.212,P<0.05); the serum ES((44.56 ± 9.34)μg/mL)and VEGF ((789.24 + 194.63)ng/L)in the distant metastasis group were significantly higher than those in the local recurrence group((36.29± 8.52)μg/mL,(612.07± 186.32)ng/L)and the nonrecurrence group((28.03 ±7.16)μg/mL,(268.95± 79.82)ng/L),the differences among the 3 groups were statistically significant(F=14.052,15.346,P<0.05);the data of the local recurrence group was higher than that in the non recurrent group,the differences were statistically significant(P<0.05);Correlation analysis showed that serum ES and VEGF were positively correlated with thyroglobulin(Thyroglobulin,Tg)in patients with recurrence and metastasis(r=0.583,0.726,P<0.05).Conclusion The serum levels of ES and VEGF in patients with differentiated thyroid cancer after operation were significantly higher than those in patients with differentiated thyroid cancer,which had certain clinical value in evaluating the recurrence or metastasis of differentiated thyroid cancer patients.